Promethazine works by blocking histamine H1 receptors, which reduces allergic responses. It also has anticholinergic, sedative, and antiemetic (anti-nausea) properties by affecting other receptors in the brain and body. It comes in forms like tablets (12.5 mg, 25 mg, 50 mg), oral syrup/solution, rectal suppositories, and injectable forms (the latter administered by healthcare providers).
It is used for short-term relief of various symptoms and is not typically a first-line long-term treatment.
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